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目的:探讨子宫颈正常组织及病变组织中pRb2/p130的表达及其与子宫颈癌临床病理特征的关系。方法:应用免疫组化SP法检测60例患者子宫颈标本的pRb2/p130的表达,其中宫颈浸润癌10例,宫颈原位癌15例,宫颈上皮内瘤变(C IN)Ⅰ-Ⅱ期15例,正常宫颈组织20例。结果:pRb2/p130阳性表达率在正常宫颈组织、C IN、宫颈原位癌、宫颈浸润癌组织中依次递减,分别为85.0%、80.0%、26.6%、20.0%,且宫颈浸润癌和宫颈原位癌(C IS)中明显低于正常宫颈组织及C IN组织,差异均有统计学意义(P<0.05)。结论:在子宫颈癌中pRb2/p130的表达下降或缺失是一个频发事件,其恶性程度愈高表达阳性率愈低,提示pRb2/p130与子宫颈癌的发生、发展密切相关,并在其发病机制中起着重要的作用。
Objective: To investigate the expression of pRb2 / p130 in normal and diseased cervical tissues and its relationship with the clinicopathological features of cervical cancer. Methods: The expression of pRb2 / p130 was detected by immunohistochemical SP method in 60 cases of cervical specimens, including 10 cases of invasive cervical carcinoma, 15 cases of cervical carcinoma in situ and 15 cases of cervical intraepithelial neoplasia (CIN) Ⅰ-Ⅱ 15 Cases, 20 cases of normal cervical tissue. Results: The positive rates of pRb2 / p130 were decreased in normal cervical tissue, C IN, cervical carcinoma in situ and invasive cervical carcinoma, which were respectively 85.0%, 80.0%, 26.6% and 20.0% Carcinoid carcinoma (C IS) was significantly lower than normal cervical tissue and C IN tissue, the difference was statistically significant (P <0.05). Conclusion: The decrease or deletion of pRb2 / p130 in cervical cancer is a frequent event, and the lower the positive rate of pRb2 / p130 is, the lower the positive rate of pRb2 / p130 is. It suggests that pRb2 / p130 is closely related to the occurrence and development of cervical cancer, Pathogenesis plays an important role.