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目的研究胎儿发育与脐血瘦素及血脂代谢的关系。方法以2009年1月至2010年6月青岛市城阳区人民医院产科分娩的符合纳入标准的新生儿共132例为研究对象,测定脐血瘦素、胆固醇及甘油三酯。按不同出生体质量、胎龄及不同胎龄与出生体质量的足月儿进行分类研究。结果脐血瘦素及甘油三酯在巨大儿组明显高于正常出生体质量儿组(P<0.05),低出生体质量儿组则明显降低(P<0.01),足月儿较早产儿明显升高(P<0.05)。妊娠34周以前脐血瘦素水平很低,随着妊娠时间的延长,脐血瘦素水平提高,特别是妊娠34周以后,脐血瘦素水平增高明显(P<0.01),宫内发育迟缓足月儿脐血瘦素明显降低,甘油三酯及胆固醇无明显改变。结论脐血瘦素水平可以反映胎儿脂肪组织的含量,可作为评价胎儿宫内营养状态的指标。
Objective To study the relationship between fetal development and cord blood leptin and blood lipid metabolism. Methods A total of 132 newborns who met the inclusion criteria of obstetric delivery from January 2009 to June 2010 in Chengyang People’s Hospital of Qingdao City were enrolled in this study. Serum leptin, cholesterol and triglyceride were measured. According to different birth weight, gestational age and gestational age and birth weight of full-term children were classified. Results Cord blood leptin and triglyceride levels were significantly higher in the macular group than in the normal birth weight group (P <0.05), while those in the low birth weight group were significantly lower (P <0.01) Increased (P <0.05). Cord blood leptin level is very low before 34 weeks of gestation, and cord blood leptin level increases with the extension of gestation time. Especially after 34 weeks gestation, cord blood leptin level increased significantly (P <0.01), intrauterine growth retardation Full-term children with cord blood leptin decreased significantly, no significant changes in triglycerides and cholesterol. Conclusion Cord blood leptin level can reflect the content of fetal adipose tissue, can be used as an indicator of fetal intrauterine nutrition status.