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目的研究慢性心力衰竭(CHF)患者不同心功能状态下血清肿瘤抗原125(CA125)水平的改变及其临床意义。方法对32例CHF患者按照纽约心功能分级标准分为心功能Ⅰ级和Ⅱ级组(A组)17例心功能Ⅲ级和Ⅳ级组(B组)15例,用化学发光法测定其血清CA125水平,并与25例健康人比较。结果CHF患者血清CA125平均水平高于对照组(P<0.01),B组血清CA125平均水平高于A组。结论血清CA125水平与CHF患者心功能相关,临床上观察CA125的水平变化可以作为评价CHF患者心功能的一个重要指标。
Objective To study the changes and clinical significance of serum tumor antigen 125 (CA125) in patients with chronic heart failure (CHF) under different cardiac functions. Methods Thirty-two CHF patients were divided into two groups according to New York Heart Association grading criteria. Seventeen patients with grade Ⅲ and Ⅳ cardiac function (group A) and 15 patients with grade Ⅳ cardiac function (group B) were measured by chemiluminescence CA125 level, and compared with 25 healthy people. Results The average level of serum CA125 in patients with CHF was higher than that in control group (P <0.01). The average level of serum CA125 in group B was higher than that in group A. Conclusions Serum CA125 level correlates with cardiac function in patients with CHF. Clinically, the level of CA125 can be used as an important index to evaluate the cardiac function in patients with CHF.