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应用免疫组织化学方法检测RKIP蛋白和NPRL2蛋白在52例口腔涎腺腺样囊性癌组织、26例癌旁腺样囊性癌组织及15例正常涎腺组织中的表达,并分析RKIP和NPRL2的表达与腺样囊性癌临床病理学特征的关系。结果:免疫组化结果显示腺样囊性癌组织、癌旁及正常涎腺组织中RKIP和NPRL2的阳性率分别为48.08%、76.92%、93.33%和46.15%、80.77%、93.33%;腺样囊性癌组织中RKIP和NPRL2的表达显著低于癌旁及正常涎腺组织,差异有统计学意义
Immunohistochemistry was used to detect the expression of RKIP protein and NPRL2 protein in 52 cases of salivary adenoid cystic carcinoma, 26 cases of paracancerous adenoid cystic carcinoma and 15 cases of normal salivary gland tissues. The expressions of RKIP and NPRL2 And the clinicopathological features of adenoid cystic carcinoma. Results: The positive rates of RKIP and NPRL2 in adenoid cystic carcinoma, paracancer and normal salivary glands were 48.08%, 76.92%, 93.33% and 46.15%, 80.77% and 93.33% respectively by immunohistochemistry. The expression of RKIP and NPRL2 in cancerous tissues was significantly lower than that in paracancerous tissues and normal salivary glands, the difference was statistically significant