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许多从事矽肺研究工作者都认为石英破坏巨噬细胞是矽肺发病的一个重要环节。当肺泡巨噬细胞吞噬了石英粉尘,细胞被石英破坏,石英从细胞中溢出,然后再被吞噬。同时由于肺泡巨噬细胞不断地破坏,导致肺部发生纤维化作用,最后形成了矽结节。我们为了进一步了解矽肺发病过程和药物作用的原理,首先对石英引起的肺泡巨噬细胞结构与功能的改变做了初步探讨,同时也观察了一些治疗矽肺有效的药物在阻止石英破坏肺泡巨噬细胞这一作用上的表现,企图从中能找到一些规律,以便为寻找新的有
Many silicosis researchers believe that quartz destruction of macrophages is an important part of silicosis. When alveolar macrophages engulf quartz dust, the cells are destroyed by quartz, quartz spills from the cell, and then is swallowed. At the same time as the alveolar macrophages continue to destroy, leading to fibrosis in the lungs, and finally formed a silicone nodules. In order to further understand the pathogenesis of silicosis and the role of drugs, we first made a preliminary study on the changes of the structure and function of alveolar macrophages induced by quartz, and also observed that some drugs that are effective in the treatment of silicosis prevent quartz from damaging alveolar macrophages This role in performance, in an attempt to find some rules, in order to find new ones