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目的:探讨降钙素原(PCT)、C-反应蛋白(CRP)在慢性阻塞性肺病(COPD)患者急性加重期与呼吸道细菌感染之间的相关性。方法:收集178例COPD患者,分别进行PCT、CRP检测和痰培养。结果:PCT在非致病菌感染组与细菌感染组、真菌感染组之间,细菌感染组与真菌感染组,G-菌感染组与G+菌感染组比较差异有统计学意义。在非致病菌组与致病菌组中PCT阳性率比较差异有统计学意义。CRP仅在非致病菌感染组与细菌感染组、真菌感染组比较差异有统计学意义。结论:PCT有助于判别机体是否处于肺部感染状态,帮助区分真菌或细菌感染,而且在鉴别G-菌和G+菌感染上有一定价值,其精确性和特异性均高于CRP。
Objective: To investigate the correlation between procalcitonin (PCT) and C-reactive protein (CRP) in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and bacterial infections of the respiratory tract. Methods: A total of 178 patients with COPD were collected for detection of PCT and CRP and sputum culture. Results: There was significant difference in PCT between non-pathogenic bacteria infection group and bacterial infection group, fungal infection group, bacterial infection group and fungal infection group, G-bacteria infection group and G + bacteria infection group. The positive rate of PCT in non-pathogenic bacteria group and pathogenic bacteria group was statistically significant difference. CRP only in non-pathogenic bacteria infection group and bacterial infection group, fungal infection group differences were statistically significant. CONCLUSIONS: PCT is useful in determining whether an organism is in a pulmonary infection, assisting in distinguishing fungal or bacterial infections, and is valuable in identifying G- and G-cell infections with greater accuracy and specificity than CRP.