论文部分内容阅读
目的探讨基质金属蛋白酶MM-2、MM-9和超敏C-反应蛋白(hs-CPR)在急性冠脉综合征(ACS)中的变化及对预后的影响。方法选择2006年3月至2010年5月住院的ACS患者120例为观察组;其中不稳定型心绞痛(UA)40例、无sT段抬高心肌梗死(NSTEMI)40例、急性ST段抬高心肌梗死(STEMI)40例。另选择同期稳定心绞痛患者40例为对照组,采用酶联免疫吸附法测定两组MM-2、MM-9水平,用免疫散射比浊法测定hs-CRP水平,并分析MM-2、MM-9及hs-CRP的变化和冠脉病变之间的关系。结果观察组血清MM-2、MM-9及hs-CRPR的水平高于对照组(P<0.05),NSTEMⅠ组和STEMⅠ组血清MM-2、MM-9及hs-CRP的水平高于UA组,有统计学意义(P<0.05),而NSTEMⅠ组和STEMⅠ组比较无统计学意义(P>0.05);观察组患者血清MMP-2与hs-CRP无明显相关性(r=0.25,P=0.05),而血清MMP-9与hs-CRP水平呈正相关(r=0.599,(P<0.05)。结论联合检测ACS患者血清MMP-2、MMP-9和hs-CRP对判断斑块稳定性、预测ACS的危险分层及预后有重要的指导意义。
Objective To investigate the changes of matrix metalloproteinase-2, MM-9 and hs-CPR in patients with acute coronary syndrome (ACS) and their prognostic significance. Methods A total of 120 hospitalized ACS patients from March 2006 to May 2010 were enrolled in this study. Among them, 40 patients with unstable angina pectoris (UA), 40 patients without sT elevation myocardial infarction (NSTEMI) and acute ST-segment elevation Myocardial infarction (STEMI) in 40 cases. Another 40 patients with stable angina at the same period were chosen as the control group. The levels of MM-2 and MM-9 were measured by enzyme-linked immunosorbent assay. The levels of hs-CRP were determined by immune nephelometry. The levels of MM-2, MM- 9 and hs-CRP changes and the relationship between coronary lesions. Results The levels of serum MM-2, MM-9 and hs-CRPR in the observation group were higher than those in the control group (P <0.05). The serum levels of MM-2, MM-9 and hs-CRP in the NSTEMⅠand STEMⅠgroups were higher than those in the UA group (P <0.05), but there was no significant difference between NSTEMⅠgroup and STEMⅠgroup (P> 0.05). There was no significant correlation between serum MMP-2 and hs-CRP in the observation group (r = 0.25, P = 0.05), but there was a positive correlation between serum MMP-9 and hs-CRP levels (r = 0.599, P <0.05) .Conclusion Serum MMP-2, MMP-9 and hs- Predict the risk stratification and prognosis of ACS have important guiding significance.