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本实验研究邻苯二酚单取代胺羧酰胺类螯合剂对铀的促排解毒作用。实验证明１８个该类螯合剂均有一定的促排作用，４８ｈ尿铀排出量与对照组相比，比值在１．２１～２．５１之间，其中双酚酰胺丁酸（Ｎｏ．１６）促排效果最好，大白鼠ｉｍ０．２５ｇ·ｋｇ－１，尿铀比值达２．５１，ｉｇ０．５ｇ·ｋｇ－１或１ｇ·ｋｇ－１也可提高尿铀排出量。解毒试验表明小白鼠ｓｃ双酚酰胺丁酸使铀中毒ＬＤ５０提高到１６．４倍，ｉｇ给药可提高到７．６倍；大白鼠ｉｇ给药可使铀中毒ＬＤ５０提高到３．９倍；延迟４ｈｉｇ仍然有效。此外双酚酰胺丁酸可显著降低小白鼠因ＮｉＣｌ２、ＭｎＣｌ２、ＣｏＣｌ２中毒引起的死亡数。
The experimental study of catechol monosubstituted amine carboxamide chelating agent on the role of promoting the detoxification of uranium. Experiments show that 18 kinds of chelating agents have a certain role in promoting the discharge of 48h urinary uranium emissions compared with the control group, the ratio between 1.21 ~ 2.51, of which bisphenol amidobutyrate (No.16) The best curative effect is that im0.25g · kg-1 and uranium ratio of 2.51, ig0.5g · kg-1 or 1g · kg-1 can also improve urinary uranium excretion. The detoxification tests showed that the mice sc bisphenol amidobutyrate uranium poisoning LD50 increased to 16.4 times, ig administration can be increased to 7.6 times; rat ig administration can uranium poisoning LD50 increased to 3.9 times; Delay 4hig is still valid. In addition BPA can significantly reduce mice caused by NiCl2, MnCl2, CoCl2 poisoning caused by the number of deaths.