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目的:分析老年人群阿司匹林抵抗(AR)情况及临床相关因素。方法:入选长期服用阿司匹林的汉族老年人(100mg/d,3个月以上),共300例(男196例,女104例),年龄65～84岁。检测分别由二磷酸腺苷和花生四烯酸诱导的血小板聚集率。根据检测结果,将患者分为AR组和阿司匹林敏感(AS)组。记录入选对象性别、年龄、病程、血常规、服用非甾体消炎药及质子泵抑制剂药物史、吸烟史、血脂异常史、糖尿病史。结果:AR组老人红细胞数量、吸烟者、服用非甾体消炎药及质子泵抑制剂者、患高胆固醇血症者百分比高于AS组。Logistic回归分析显示,年龄、性别、吸烟史、红细胞计数对于AR的发生具有独立的影响。结论:在老年人群中,血红细胞数量、服用非甾体消炎药及质子泵抑制剂、吸烟、高胆固醇血症与AR有关。而年龄、性别、吸烟史、红细胞计数是AR发生的独立影响因素。
Objective: To analyze the aspirin resistance (AR) in the elderly and the related clinical factors. Methods: A total of 300 Chinese Han elderly (100 mg / d, over 3 months) were enrolled in long-term aspirin treatment. A total of 300 Han patients (196 males and 104 females) aged 65-84 years were enrolled. The platelet aggregation rate induced by adenosine diphosphate and arachidonic acid, respectively, was examined. According to the test results, the patients were divided into AR group and aspirin sensitive (AS) group. The subjects’ gender, age, course of disease, blood routine, medication history of non-steroidal anti-inflammatory drugs and proton pump inhibitors, smoking history, history of dyslipidemia and history of diabetes mellitus were recorded. Results: The percentage of elderly erythrocytes, smokers, non-steroidal anti-inflammatory drugs and proton pump inhibitors in AR group were higher than those in AS group. Logistic regression analysis showed that age, sex, smoking history and erythrocyte count had independent effects on the occurrence of AR. Conclusion: In the elderly population, the number of red blood cells, taking non-steroidal anti-inflammatory drugs and proton pump inhibitors, smoking, hypercholesterolemia and AR. However, age, gender, smoking history and erythrocyte count were independent influencing factors of AR.