论文部分内容阅读
目的探讨二甲双胍联合炔雌醇环丙孕酮对海南地区瘦型多囊卵巢综合征(PCOS)不孕症患者性激素水平及妊娠的影响。方法 271例瘦型PCOS不孕症患者,根据治疗方案分为观察组(135例)与对照组(136例)。对照组给予炔雌醇环丙孕酮治疗,观察组在对照组基础上联合二甲双胍治疗。对比两组治疗前后卵泡生成激素(FSH)、黄体生成激素(LH)、雌二醇(E2)、孕酮(P)、睾酮(T)水平,治疗后随访3个月,统计两组排卵率及妊娠率。结果治疗后观察组FSH、LH、T水平低于对照组(P<0.05);排卵率74.81%(101/135)、妊娠率40.74%(55/135)均高于对照组52.94%(72/136)、27.94%(38/136)(P<0.05)。结论二甲双胍与炔雌醇环丙孕酮联合治疗瘦型PCOS不孕症患者,可降低性激素水平、提高排卵及妊娠率。
Objective To investigate the effect of metformin combined with ethinylestradiol and cyproterone on sex hormones and pregnancy in patients with steroid-induced polycystic ovary syndrome (PCOS) in Hainan province. Methods 271 cases of PCOS patients with infertility were divided into observation group (135 cases) and control group (136 cases) according to the treatment plan. The control group was given ethinyl estradiol cyproterone treatment, and the observation group was treated with metformin on the basis of the control group. The levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P) and testosterone (T) in both groups were compared before and after treatment. And pregnancy rate. Results After treatment, the levels of FSH, LH and T in the observation group were lower than those in the control group (P <0.05). The ovulation rate was 74.81% (101/135) and the pregnancy rate was 40.74% (55/135) 136), 27.94% (38/136) (P <0.05). Conclusion Metformin and ethinyl estradiol cyproterone combined treatment of patients with lean PCOS infertility can reduce the level of sex hormones and improve ovulation and pregnancy rate.