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已知阿片拮抗剂对动物失血性和内毒素性休克有明显的促血压回升作用,但对心源性休克的作用却研究甚少。本实验初步研究了长效阿片拮抗剂纳屈酮(naltrexone,NTX)和一种新型特异性阿片к受体拮抗剂纳美芬(nalmefene,NMF)对心源性休克大鼠平均动脉压(MAP)和心电图(ECG)的影响。 体重250～300 g雄性SD大鼠,戊巴比妥纳腹腔麻醉(50 mg/kg),记录动物MAP、心率和ECG,尔后作开胸手术,迅速结扎左冠状动脉下降支后关闭胸腔。大鼠急性心源性休克诊断标准为:MAP较结扎前(15.9±0.7kPa)下降4kPa以上;ECG的T波显著抬高;股静脉注入染料后其心室肌前壁不变色。
Opiate antagonists are known to have a significant antihypertensive effect on hemorrhagic and endotoxic shock in animals, but little is known about their role in cardiogenic shock. In this study, we investigated the effects of naltrexone (NTX), a long-acting opioid antagonist, and nalmefene (NMF), a novel opioid receptor antagonist, on the changes of mean arterial pressure ) And electrocardiogram (ECG). Male Sprague Dawley rats weighing 250-300 g were anesthetized with pentobarbital (50 mg / kg). MAP, heart rate and ECG were recorded. Thoracotomy was performed immediately followed by rapid ligation of the descending branch of the left coronary artery to close the thorax. The diagnostic criteria for acute cardiogenic shock in rats were: the MAP decreased more than 4 kPa before the ligation (15.9 ± 0.7 kPa), the T wave was significantly elevated in the ECG, and the anterior wall of the ventricular muscle did not change color after the femoral vein was infused with dye.