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女性生殖系统疾病很大程度上与雌、孕激素及其受体介导信号通路失调所致细胞增殖、凋亡和分化异常有关。这些核受体的精细调控是复杂的,许多核因子参与其中。Krüppel样因子(Krüppel-like factors,KLFs)是一组与真核细胞转录调控密切相关的锌指蛋白,在女性生殖系统中普遍表达,作为类固醇激素反应的共同调控者和整合者。KLF4在子宫内膜异位症(EMs)患者的在位内膜和子宫内膜肿瘤中表达减少。围着床期,KLF5在子宫内膜容受性的形成中起重要作用,与胚胎成功植入有关。KLF6参与胎盘发育和妊娠的维持。KLF9对孕激素受体起正向调节作用,而对雌激素受体起到负向调节作用。KLF11是一种转录抑制因子,具有潜在地抑制子宫肌瘤、EMs异位病灶生长的功能。深入探讨KLFs的生物功能,对认识女性生殖系统疾病的发病机制有重要意义。
Female reproductive system diseases largely associated with estrogen, progesterone and its receptor-mediated cell proliferation, apoptosis and abnormal differentiation caused by dysregulation of signaling pathways. Fine regulation of these nuclear receptors is complex and many nuclear factors are involved. Krüppel-like factors (KLFs), a group of zinc finger proteins closely related to eukaryotic transcriptional regulation, are commonly expressed in the female reproductive system as co-regulators and integrators of steroid hormone responses. KLF4 is reduced in eutopic and endometrial tumors in patients with endometriosis (EMs). Around the bed, KLF5 plays an important role in the formation of endometrial receptivity, which is related to successful embryo implantation. KLF6 is involved in placental development and maintenance of pregnancy. KLF9 progesterone receptor plays a positive regulatory role, while estrogen receptors play a negative regulatory role. KLF11 is a transcriptional repressor that has the potential to inhibit the growth of uterine fibroids and ectopic EMs. In-depth exploration of the biological function of KLFs is of great significance for understanding the pathogenesis of female reproductive system diseases.