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目的 :研究Fas在肺癌中的表达及其与肺癌发生发展和预后的关系。方法 :用免疫组化SP法检测了 40例肺癌原发灶 ,9例淋巴结转移及 2 0例正常肺组织中Fas的表达。结果 :85 % (17/ 2 0 )的正常肺组织Fas表达阳性 ,47 5 % (19/ 40 )的肺癌组织Fas表达阳性 ,两组间差异具有显著性 (P <0 .0 5 ) ;9例淋巴结转移灶中均未检测到Fas的表达 ,提示Fas的表达与肿瘤的转移有一定关系。结论 :肺癌细胞通过Fas的下调表达 ,逃避机体的免疫监视 ,可能与肺癌的发生及转移密切相关
Objective: To study the expression of Fas in lung cancer and its relationship with the occurrence, development and prognosis of lung cancer. Methods : Immunohistochemical SP method was used to detect the expression of Fas in 40 cases of primary lung cancer, 9 cases of lymph node metastasis and 20 cases of normal lung tissues. Results: Fas expression was positive in 85% (17/20) normal lung tissues, and Fas expression was positive in 47.5% (19/40) lung cancer tissues. There was a significant difference between the two groups (P < 0.05); 9 No expression of Fas was detected in lymph node metastases, suggesting that Fas expression was related to tumor metastasis. Conclusion: The down-regulation of Fas expression in lung cancer cells evades the body’s immune surveillance and may be closely related to the occurrence and metastasis of lung cancer.