脓毒症病情凶险,病死率高,据WHO 2010年统计,全世界每年大约1000人中就有3人发生脓毒症和感染性休克,同时这一数字还呈现不断增长的趋势,以每年1.5%～8.0%的速度上升。近年来,抗感染治疗和器官功能支持技术取得了长足的进步,但该病的死亡率仍高达30%～70%。本文结合临床实际,就脓毒血症的发生机制、临床治疗及研究进展作一综述。 Sepsis is extremely dangerous and has a high case fatality rate. According to WHO’s 2010 statistics, sepsis and septic shock occur in about 3 out of 1000 people in the world each year, and the number is also on the rise at an annual rate of 1.5 % ~ 8.0% increase in speed. In recent years, advances in anti-infective therapy and organ function support have been made, but the mortality rate is still as high as 30% -70%. In this paper, clinical practice, the pathogenesis of sepsis, clinical treatment and research progress are reviewed.