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目的:研究肝舒康冲剂对肝纤维化的防治作用。方法:采用二甲基亚硝胺(DMN)所致大鼠肝纤维化模型,研究肝舒康冲荆对大鼠血清透明质酸(HA)和Ⅲ型前胶原(PC Ⅲ)及病理组织形态学的影响。结果:肝舒康冲剂能降低肝纤维化血清学指标HA、PC Ⅲ数值,改善肝组织病理损害,明显优于对照组(P<0.05～0.01)。结论:肝舒康冲剂具有良好的预防和治疗肝纤维化效果。
Objective: To study the preventive and therapeutic effects of Ganshukang Granules on hepatic fibrosis. METHODS: Rat hepatic fibrosis model induced by dimethylnitrosamine (DMN) was used to study the effects of Ganshukangjing on serum hyaluronic acid (HA), type III procollagen (PC III) and pathological histomorphology in rats. influences. RESULTS: Ganshukang Granule could reduce the serum HA and PC III values of hepatic fibrosis and improve liver pathological damage, which was significantly better than the control group (P<0.05-0.01). Conclusion: Ganshukang Granule has a good effect of preventing and treating liver fibrosis.