动脉粥样硬化(AS)是由一系列细胞及分子参与的炎症反应性疾病,在AS发生发展的过程中氧化低密度脂蛋白(ox-LDL)发挥了极其重要的作用。其主要通过2种机制促进AS病变进展:一是通过巨噬细胞的清道夫受体进入细胞,促进细胞的泡沫化,进而泡沫细胞堆积,促进血管内壁脂纹形成;二是引起 Atherosclerosis (AS) is a inflammatory reaction disease involving a series of cells and molecules. Oxidized low density lipoprotein (ox-LDL) plays an extremely important role in the development of AS. It is mainly through two mechanisms to promote the progress of AS lesions: First, the scavenger receptor through the macrophages into the cell, and promote cell foam, thereby foam cell accumulation, and promote the formation of vascular wall lipid pattern; the second is caused