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目的研究颅脑损伤患者血清脑红蛋白含量与神经损伤程度的相关性。方法选择2012年4月~2015年10月在延安大学附属医院(以下简称“我院”)收治的38例颅脑外伤患者作为观察组,包括轻度损伤13例、中度损伤16例、重度损伤9例;选择同期在我院体检的40例健康志愿者作为对照组,采集两组患者的血清并测定脑红蛋白(NGB)、泛素羧基末端水解酶-L1(UCH-L1)、神经元特异性烯醇化酶(NSE)、S100β蛋白、胶质纤维酸性蛋白(GFAP)的含量,采用全面无反应性量表(FOUR)评价观察组患者的神经功能。结果观察组患者的血清NGB[(325.27±55.11)比(57.33±8.15)pg/m L]、UCH-L1[(1.14±0.17)比(0.15±0.02)ng/m L]、NSE[(32.46±6.11)比(6.71±0.82)ng/m L]、S100β[(1.05±0.16)比(0.53±0.08)pg/m L]、GFAP[(22.52±4.18)比(10.69±1.73)pg/m L]含量显著高于对照组,差异均有统计学意义(P<0.05);颅脑损伤程度越严重,血清NGB、UCH-L1、NSE、S100β、GFAP的含量越高,睁眼反应、运动反应、脑干反射、呼吸节律评分越低(P<0.05);血清NGB含量与UCH-L1、NSE、S100β、GFAP含量均呈正相关(r=0.668、0.637、0.701、0.725,均P<0.05);血清NGB含量与睁眼反应、运动反应、脑干反射、呼吸节律评分均呈负相关(r=-0.628、-0.714、-0.683、-0.709,均P<0.05)。结论颅脑损伤患者血清NGB含量显著升高且与神经功能的损伤程度具有良好的相关性,是评估颅脑损伤严重程度理想的实验室指标。
Objective To study the correlation between serum brain hemoglobin content and the degree of nerve injury in patients with craniocerebral injury. Methods Thirty-eight patients with craniocerebral trauma admitted to Affiliated Hospital of Yan’an University (hereinafter referred to as “Hospital”) from April 2012 to October 2015 were selected as the observation group, including 13 cases of mild injury and 16 cases of moderate injury , And severe injury in 9 cases. Forty healthy volunteers who were in our hospital during the same period were selected as the control group. The sera of two groups were collected and serum levels of NGB, UCH-L1, , Neuron specific enolase (NSE), S100β protein and glial fibrillary acidic protein (GFAP) in the observation group. The neurological function in the observation group was evaluated by the comprehensive non-responsiveness scale (FOUR). Results The serum levels of NGB [(325.27 ± 55.11) vs (57.33 ± 8.15) pg / m L] and UCH-L1 [(1.14 ± 0.17) vs 0.15 ± 0.02 ng / m L] (6.71 ± 0.82) ng / m L], S100β [(1.05 ± 0.16) vs (0.53 ± 0.08) pg / m L], GFAP [(22.52 ± 4.18) vs (10.69 ± 1.73) pg / m (P <0.05). The more serious the brain injury was, the higher the content of serum NGB, UCH-L1, NSE, S100β and GFAP were. (P <0.05). Serum NGB levels were positively correlated with the levels of UCH-L1, NSE, S100β and GFAP (r = 0.668,0.637,0.701,0.725, all P <0.05) Serum NGB levels were negatively correlated with open-eye reaction, motor response, brainstem reflex, and respiratory rhythm scores (r = -0.628, -0.714, -0.683, -0.709, all P <0.05). Conclusion Serum NGB levels are significantly increased in patients with craniocerebral injury and have a good correlation with the degree of neurological damage. It is an ideal laboratory index for assessing the severity of craniocerebral injury.