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目的 :研究慢性化脓中耳炎主要病原菌的种类及对抗生素的耐药情况。方法 :对 16 2例慢性化脓性中耳炎患者的耳分泌物进行细菌培养 ,对分离的病原菌进行药物敏感试验。结果 :分离出病原菌 183株 ,以金黄色葡萄球菌 (6 3株 )和铜绿假单胞菌 (57株 )为主 ,金黄色葡萄球菌对青霉素和红霉素的耐药性率分别为 10 0 %和 71 4 % ,对氨基糖甙类、氟喹诺酮类和头孢类抗生素敏感性较高 ;铜绿假单胞菌对氨苄西林、头孢类抗生素耐药率较高 ,对氟喹诺酮类、氨基糖甙类抗生素敏感。结论 :金黄色葡萄球菌和铜绿假单胞菌是济南地区慢性化脓性中耳炎的主要致病菌 ,二者对青霉素类抗生素有较高的耐药率。临床医师不能仅凭经验 ,而应根据细菌培养和药敏结果用药 ,以防耐药菌株产生
Objective: To study the types of major pathogens in chronic suppurative otitis media and their resistance to antibiotics. Methods: Bacterial culture was performed on the ear secretions of 16 2 patients with chronic suppurative otitis media. Drug-sensitive tests were performed on the isolated pathogens. Results: A total of 183 pathogens were isolated from Staphylococcus aureus (63 strains) and Pseudomonas aeruginosa (57 strains). The drug resistance rates of Staphylococcus aureus to penicillin and erythromycin were 10 0 % And 71 4% respectively. The sensitivity to aminoglycosides, fluoroquinolones and cephalosporins was high. The resistance rate of Pseudomonas aeruginosa to ampicillin and cephalosporins was high, and the fluoroquinolones, aminoglycosides Antibiotic-sensitive. Conclusion: Staphylococcus aureus and Pseudomonas aeruginosa are the main pathogens of chronic suppurative otitis media in Ji’nan. Both of them have a high resistance rate to penicillin antibiotics. Clinicians should not rely solely on experience, but should use drugs based on bacterial culture and susceptibility to prevent the emergence of drug-resistant strains