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目的：探索地尔硫对肥厚性心肌病（ＨＣＭ）病人左心室舒张功能与室间隔厚度（ＩＶＳＴ）的影响。方法：３２例ＨＣＭ病人（男性２１例，女性１１例；年龄４８ａ±ｓ１０ａ）给地尔硫片３０～６０ｍｇ，ｐｏ，ｔｉｄ×５ａ，给药前、给药后０．５ａ与５ａ进行超声心动图检查。结果：地尔硫治疗０．５ａ左心室舒张功能包括等容舒张时间、Ｅ峰减速度与舒张早期加速度面积（ＥＡＡ）已有显著改善（Ｐ＜０．０１或Ｐ＜０．０５）；治疗５ａ上述效应进一步增加；同时ＩＶＳＴ及左心房内径有轻度减退趋势（Ｐ＞０．０５）。结论：长期服用地尔硫能持续改善ＨＣＭ病人的左室舒张功能、抑制室间隔的进一步增厚。
Objective: To explore the effect of diltiazem on left ventricular diastolic function and interventricular septal thickness (IVST) in patients with hypertrophic cardiomyopathy (HCM). Methods: Thirty-two patients with HCM (21 males and 11 females; age 48a ± s10a) were given 30 ~ 60mg, po, tid × 5a of diltiazem tablets before and 0.5a and 5a after the administration Cardiogram examination. Results: Diltiazem had a significant improvement in left ventricular diastolic function including isovolumetric relaxation time, E peak deceleration and early diastolic acceleration area (EAA) (P <0.01 or P <0.05). The above effects were further increased in the treatment of 5a, while the IVST and the left atrial diameter had a slight decrease (P> 0.05). Conclusion: Long-term use of diltiazem can continue to improve left ventricular diastolic function in patients with HCM and inhibit further ventricular septal thickening.