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目的探讨2型糖尿病(T2DM)患者尿白蛋白排泄率(UAER)与颈动脉内膜中层厚度(CIMT)的相关关系。方法将302名T2DM住院患者根据UAER分为正常白蛋白尿组(UAER<20μg/min)103例,微量白蛋白尿组(UAER20～200μg/min)107例,临床白蛋白尿组(UAER>200μg/min)92例。所有患者均采用高分辨率超声测量CIMT水平;多因素线性相关分析UAER和CIMT的关系。结果三组间年龄、性别、体质指数具有可比性(P>0.05)。与正常白蛋白尿组相比,微量白蛋白尿组CIMT增厚,差异具有统计学意义(P<0.05);与正常白蛋白尿组及微量白蛋白尿组相比,临床白蛋白尿组CIMT增厚,差异均具有统计学意义(P<0.05)。多因素线性相关显示,UAER与CIMT呈显著正相关(r=0.716,P<0.001)。结论 UAER与CIMT关系密切,UAER水平升高是2型糖尿病患者早期大血管病变的重要危险因素。
Objective To investigate the relationship between urinary albumin excretion rate (UAER) and carotid artery intima-media thickness (CIMT) in type 2 diabetes mellitus (T2DM). Methods 302 patients with T2DM were divided into three groups according to UAER: normal albuminuria group (UAER <20μg / min), microalbuminuria group (UAER20-200μg / min), 107 cases of clinical albuminuria group / min) 92 cases. All patients were measured by high resolution ultrasound CIMT levels; multi-factor linear correlation analysis of UAER and CIMT relationship. Results The age, sex and body mass index were comparable between the three groups (P> 0.05). Compared with normal albuminuria group, microalbuminuria group CIMT thickening, the difference was statistically significant (P <0.05); compared with normal albuminuria group and microalbuminuria group, clinical albuminuria group CIMT Thickening, the differences were statistically significant (P <0.05). Multi-factor linear correlation showed that there was a significant positive correlation between UAER and CIMT (r = 0.716, P <0.001). Conclusions UAER is closely related to CIMT. UAER level is an important risk factor for early macrovascular disease in type 2 diabetic patients.