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目的探讨吲达帕胺片联合缬沙坦分散片口服对原发性高血压的干预效果,并随访2个月,观察肾功能的损伤程度。方法 100例原发性高血压患者,按随机数字法分为治疗组和对照组,每组50例。治疗组使用缬沙坦分散片联合吲达帕胺片口服治疗,对照组单独使用缬沙坦治疗,2个月后观察疗效,复查肾功能。结果治疗2个月后,治疗组有效47例(94%),对照组有效40例(80%),两组比较差异有统计学意义(P<0.05)。治疗组血肌酐、尿素氮水平与对照组相比差异无统计学意义(P>0.05),而胱抑素C(Cys C)和尿蛋白水平在治疗组明显低于对照组,差异有统计学意义(P<0.05)。结论缬沙坦分散片联合吲达帕胺片对原发性高血压疗效显著,对肾功能保护作用较好,值得临床推广。
Objective To investigate the effect of oral administration of indapamide and valsartan dispersible tablets on essential hypertension and to observe the degree of renal damage after 2 months of follow-up. Methods 100 patients with essential hypertension were randomly divided into treatment group and control group according to random number method, 50 cases in each group. The treatment group were treated with valsartan dispersible tablets combined with indapamide tablets, the control group alone with valsartan treatment, 2 months after the observation of efficacy, review of renal function. Results After treatment for 2 months, 47 cases (94%) were effective in the treatment group and 40 cases (80%) in the control group, with significant difference between the two groups (P <0.05). There was no significant difference in serum creatinine and urea nitrogen between the treatment group and the control group (P> 0.05), while the levels of cystatin C (Cys C) and urine protein in the treatment group were significantly lower than those in the control group Significance (P <0.05). Conclusion Valsartan dispersible tablets combined with indapamide tablets have a significant effect on essential hypertension and have a good protective effect on renal function, which is worthy of clinical promotion.