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目的:探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者血清降钙素原(PCT)、尿酸(UA)、白细胞计数(WBC)、空腹血糖(Glu)的变化及其在AECOPD中的临床意义。方法:收集2014年9月至2015年9月期间就诊于我院的AECOPD患者45例、COPD稳定期患者30例及健康受试者45例。分别采用荧光法、血液分析仪和生化分析仪测定受试者血清PCT、WBC、UA和Glu水平,并进行统计学分析。结果:与COPD稳定期及健康对照组相比,AECOPD患者PCT(0.23±0.23 vs.0.13±0.16,0.01±0.03)、UA(410.54±81.35 vs.324.44±57.71,264.32±52.23)、WBC(8.88±4.28 vs.7.65±1.66,6.59±1.14)、Glu(6.22±1.14 vs.5.62±0.98,4.35±0.62)水平均明显升高(P<0.05)。PCT、UA、WBC、Glu诊断AECOPD的ROC曲线下面积分别为0.834、0.939、0.643、0.933,AUCGlu>AUCPCT>AUCWBC有统计学意义(P<0.05),AUCUA>AUCGlu无统计学意义(P>0.05)。结论:PCT、UA、WBC、Glu水平对AECOPD患者具有一定的诊断意义,以UA和Glu的诊断价值更高。
Objective: To investigate the changes of serum procalcitonin (PCT), uric acid (UA), white blood cell count (WBC) and fasting blood glucose (Glu) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and its clinical significance in AECOPD . Methods: Forty-five patients with AECOPD, 30 patients with stable COPD and 45 healthy subjects were enrolled in our hospital from September 2014 to September 2015. The levels of PCT, WBC, UA and Glu in serum of the subjects were measured by fluorometry, hematology analyzer and biochemical analyzer respectively, and statistical analysis was made. Results: Compared with stable COPD patients and healthy controls, AECOPD patients had significantly lower PCT (0.23 ± 0.23 vs.0.13 ± 0.16, 0.01 ± 0.03), UA (410.54 ± 81.35 vs.324.44 ± 57.71, 264.32 ± 52.23), WBC (8.88 ± 4.28 vs.7.65 ± 1.66,6.59 ± 1.14), Glu (6.22 ± 1.14 vs.5.62 ± 0.98, and 4.35 ± 0.62), respectively (P <0.05). The area under the curve of ROC curve of AECOPD diagnosed by PCT, UA, WBC and Glu were 0.834,0.939,0.643,0.933, AUCGlu> AUCPCT> AUCWBC respectively (P <0.05), AUCUA> AUCGlu was not statistically significant ). Conclusions: The levels of PCT, UA, WBC and Glu are of diagnostic significance for patients with AECOPD. The diagnostic value of UA and Glu is higher.