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目的:调查近14年来武汉地区溃疡性结肠炎(UC)的患病情况与临床病理特点,为进一步研究UC的发病情况与危险因素提供依据。方法:回顾性收集近14年武汉市5家教学中心医院经结肠镜与病理诊断为UC的病例,统计患病情况、临床表现、内镜及病理特点以及诊断与预后。结果:近14年UC病例明显增多,呈上升趋势,但仍然是少见病。389例患者中,男女比1.53∶1,均龄42岁,平均病程3.7年。UC主要临床表现为腹泻(80.2%)、血便(75.1%)。肠外表现18例(4.6%),并发症35例(9.0%),较西方国家低。病变以初发型(40.6%)和反复发作型(44%)为主,轻中度病变多见(86.6%),部位以左半结肠炎为主(76.6%),绝大多数患者经氨基水杨酸类药物和糖皮质激素治疗有效(86%)。结论:近14年来武汉地区UC呈上升趋势,但仍是少见病。临床特点肠外表现和并发症少,病情较轻,经治疗预后较好,但诊断困难、易复发。
Objective: To investigate the prevalence and clinicopathological features of ulcerative colitis (UC) in Wuhan in the past 14 years, and provide the basis for further study on the incidence and risk factors of UC. Methods: The cases of colon cancer and pathological diagnosis of UC in five teaching center hospitals in Wuhan City were retrospectively collected. The prevalence, clinical manifestations, endoscopic and pathological features, diagnosis and prognosis were collected. Results: In the past 14 years, the number of UC cases increased significantly, but the trend was still rare. 389 patients, men and women than 1.53: 1, mean age 42 years, an average duration of 3.7 years. The main clinical manifestations of UC were diarrhea (80.2%) and bloody stool (75.1%). Extraintestinal manifestations in 18 cases (4.6%), complications in 35 cases (9.0%), lower than in Western countries. Lesions were mainly primary (40.6%) and recurrent (44%), mild to moderate (86.6%) were more common, and left mostly (76.6%) to left half colitis. Most of the patients were treated with amino-water Salicylates and glucocorticoids were effective (86%). Conclusion: The UC in Wuhan has been on the rise in the past 14 years, but it is still a rare disease. Clinical features Extraintestinal manifestations and complications less, less serious, the prognosis is good, but the diagnosis is difficult and easy to relapse.