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目的探讨十二指肠溃疡（ＤＵ）和功能性消化不良（ＦＤ）患者胃排空及血浆胃泌素和胃动素的变化规律．方法ＤＵ患者１７例（男１６例，女１例，年龄４３５岁±９９岁），ＦＤ患者２２例（男１７例，女５例，年龄４６５岁±１３０岁）为研究对象，健康志愿者１７例（男９例，女８例，年龄４５８岁±１４３岁）为对照组．应用双同位素标记试餐ＳＰＥＣＴ法检测的液体和固体食物胃排空及其胃内分布，并以ＲＩＡ法检测基础及餐后血浆胃泌素和胃动素水平变化．结果５９１％ＦＤ患者和７０６％ＤＵ患者的固体半排空时间延长，这两个病例组的固体胃排空变化相似，均表现为迟滞相消失，初始排空较快，继后的排空变慢，半排空时间延长（ＦＤ组１０２ｍｉｎ±３６ｍｉｎ，ＤＵ组９５ｍｉｎ±２７ｍｉｎ，对照组７０ｍｉｎ±１６ｍｉｎ，Ｐ均＜００５）；２组均未见胃排空加速者．ＤＵ组基础及餐后胃动素水平（ｐｍｏｌ／Ｌ，基础２８８±７５，餐后３４０±９９）高于ＦＤ组（基础１６８±６９，餐后２０９±８２，Ｐ＜００５）和对照组（基础１２４±３８，餐后１６９±３９，Ｐ均＜００５）；ＦＤ组的餐后胃泌素水平（ｐｍｏｌ／Ｌ，餐后３２±１４，Ｐ＜００１），高于ＤＵ组（餐后２?
Objective To investigate the changes of gastric emptying and plasma gastrin and motilin in patients with duodenal ulcer (DU) and functional dyspepsia (FD). Methods A total of 17 DU patients (16 males and 1 female, aged 43.5 ± 9.9 years) and 22 FD patients (17 males and 5 females, age 46.5 ± 13.0 years) For the study, 17 healthy volunteers (9 males and 8 females, aged 45.8 ± 14.3 years) served as the control group. The gastric emptying and intragastric distribution of liquid and solid foods detected by double isotope labeled test meal SPECT were measured. The basal and postprandial levels of plasma gastrin and motilin were measured by RIA. Results In 59.1% of FD patients and 70.6% of DU patients, the solid half-emptying time was prolonged. The changes of solid gastric emptying in both groups were similar, which showed that the lag phase disappeared and the initial emptying was rapid. (FD group, 102min ± 36min, DU group, 95min ± 27min, control group, 70min ± 16min, P <005). There was no acceleration of gastric emptying in the two groups. The levels of basal and postprandial motilin in the DU group (basal 288 ± 75, postprandial 340 ± 99) were significantly higher than those in the FD group (basal 168 ± 69, postprandial 209 ± 82, P <005) Group (basal 124 ± 38, postprandial 169 ± 39, P <005); postprandial gastrin level (pmol / L, postprandial 32 ± 14, P <001) in FD group was higher than DU group (postprandial 2?