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近年来,世界上开始日益广泛地研制和使用抗肿瘤制剂。按化学结构它们属于不同种类的化学物质:烷化剂(环磷酰胺)、代谢抑制剂(氟脲嘧啶)、损伤染色体结构的物质(长春新碱)和激素类(乙烯雌酚)。这些制剂对人和动物能产生细胞毒效应,对胚胎和胎儿特别敏感。现已查明,许多抗肿瘤制剂具有致癌、致突变和致畸性。据报道,妊娠期使用治疗剂量的抗肿瘤制剂可导致子代发育缺陷。对医院有关科室室内空气测定的结果发现,空气中有抗肿瘤制剂存在。它们可通过吸
In recent years, the world has begun to increasingly develop and use anti-neoplastic agents. According to their chemical structure they belong to different kinds of chemical substances: alkylating agents (cyclophosphamide), metabolic inhibitors (fluorouracil), substances that damage the chromosome structure (vincristine) and hormones (ethylene estradiol). These preparations produce cytotoxic effects on humans and animals and are particularly sensitive to embryos and fetuses. It has been found that many anti-tumor agents are carcinogenic, mutagenic, and teratogenic. It has been reported that the use of a therapeutic dose of an anti-neoplastic agent during pregnancy can lead to developmental defects in offspring. As a result of the indoor air measurement in the relevant departments of the hospital, it was found that anti-neoplastic agents existed in the air. They can suck