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目的评价３种小剂量米非司酮用于紧急避孕的临床效果、副反应和对月经的影响。方法将６３９例年龄在１８～４５岁、无避孕或避孕措施失败性交后５天（１２０小时）以内，要求采用补救措施以防止意外妊娠的健康妇女，随机分为３组。组Ⅰ口服米非司酮５０ｍｇ；组Ⅱ口服２５ｍｇ；组Ⅲ口服１０ｍｇ。用门诊随访形式，观察用药后的副反应和妊娠与否。结果３组紧急避孕的临床效果分别为：９３．４％、９３．３％和９３．８％（Ｐ＞０．０５）。口服米非司酮后恶心、呕吐等副反应程度都较轻，无需特殊处理。无副反应者的比率，随着米非司酮用药剂量的减少而明显增加（Ｐ＜０．０５）。１２％～１４％月经提前来潮，２５％～２８％月经来潮延迟。组Ⅰ月经延迟的平均天数（１１天）比组Ⅲ（８天）明显增加（Ｐ＜０．０５）。结论米非司酮３种剂量（５０ｍｇ、２５ｍｇ和１０ｍｇ）用于性交后５天内紧急避孕都能安全、有效地防止意外妊娠
Objective To evaluate the clinical effects, side effects and effects on menstrual flow of three types of low dose mifepristone for emergency contraception. Methods A total of 639 healthy women aged 18-45 years without any contraception or contraception within 5 days after failure of sexual intercourse (120 hours) were enrolled in this study. Healthy women requiring remedial measures to prevent unwanted pregnancies were randomly assigned to 3 groups. Group Ⅰ oral mifepristone 50mg; group Ⅱ oral 25mg; group Ⅲ oral 10mg. With outpatient follow-up form, observe the side effects after treatment and pregnancy or not. Results The clinical effects of emergency contraception in the three groups were 93.4%, 93.3% and 93.8%, respectively (P> 0.05). Oral mifepristone nausea, vomiting and other side effects are mild, without special treatment. The rate of no-responders was significantly increased with decreasing doses of mifepristone (P <0.05). 12% to 14% menstrual cramps, 25% to 28% delayed menstruation. The mean number of menstrual delay in group I (11 days) was significantly higher than that in group III (8 days) (P <0.05). Conclusion Three doses of mifepristone (50mg, 25mg and 10mg) can be used safely and effectively to prevent unwanted pregnancy within 5 days after sexual intercourse