目的观察口服二甲双胍片治疗2型糖尿病的临床效果。方法 69例2型糖尿病患者口服二甲双胍片500mg/次,2次/d。治疗3个月之后,观察患者空腹血糖(FBG)、空腹胰岛素(FINS)、餐后2h血糖(2hBG)、餐后2h胰岛素(2hINS)、糖化血红蛋白(HbAlc)、血脂、体重指数(BMI)等临床指标的变化情况。结果二甲双胍显著降低血糖、胰岛素、糖化血红蛋白水平及TC、TG、LDL-C和体重指数,显著升高高密度脂蛋白量(HDL-C)(p<0.01)。结论二甲双胍是较好的2型糖尿病治疗药物。 Objective To observe the clinical effect of oral metformin on type 2 diabetes mellitus. Methods 69 patients with type 2 diabetes were treated with metformin 500 mg twice daily. After 3 months of treatment, the fasting blood glucose (FBG), fasting insulin (FINS), 2h postprandial blood glucose (2hBG), 2h insulin, HbAlc, lipids, body mass index Clinical indicators of changes. Results Metformin significantly reduced the levels of blood glucose, insulin, glycosylated hemoglobin, TC, TG, LDL-C and body mass index, and significantly increased HDL-C (p <0.01). Conclusion Metformin is a good treatment for type 2 diabetes.