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目的观察纳美芬在苯二氮类药物中毒治疗过程中的疗效。方法 129例苯二氮类药物中毒患者,随机分为研究组(64例)和对照组(65例),除常规治疗(吸氧、洗胃、导泄、利尿、补液等基础治疗)外,对照组给予纳洛酮治疗,研究组给予纳美芬治疗。比较两组患者不同意识障碍到清醒时所用时间。结果浅昏迷状态下研究组和对照组从昏迷到清醒所用时间分别为(6.30±1.01)、(8.95±1.48)h;中昏迷状态下研究组和对照组从昏迷到清醒所用时间分别为(22.44±4.52)、(28.73±6.09)h;深昏迷状态下研究组和对照组从昏迷到清醒所用时间分别为(38.33±7.34)、(52.67±9.29)h,两组比较差异均有统计学意义(P<0.05)。结论纳美芬在治疗苯二氮类药物中毒过程中能明显缩短昏迷到清醒所用时间,治疗效果较好,值得临床推广。
Objective To observe the efficacy of nalmefene in the treatment of benzodiazepine poisoning. Methods A total of 129 patients with benzodiazepine poisoning were randomly divided into study group (64 cases) and control group (65 cases). In addition to conventional treatment (basic treatment such as oxygen inhalation, gastric lavage, drainage, diuretic and rehydration) The control group was given naloxone and the study group was given nalmefene. Compare the two groups of patients with different cognitive disorders to waking time. Results The time from coma to awake in study group and control group was (6.30 ± 1.01) and (8.95 ± 1.48) h, respectively. The time from coma to awake in study group and control group in coma was (22.44 ± 4.52), (28.73 ± 6.09) h respectively. The time from coma to awake in study group and control group was (38.33 ± 7.34) and (52.67 ± 9.29) h respectively in deep coma state, the differences between the two groups were statistically significant (P <0.05). Conclusion Nalmefene can significantly shorten the time of coma and sober during the treatment of benzodiazepine poisoning, and the treatment effect is better, which is worthy of clinical promotion.