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多发性骨髓瘤(MM)是以骨髓中大量恶性浆细胞增生并伴有广泛溶骨病变为特征的B细胞系恶性肿瘤,好发于老年人,约占人类癌症总发生率的1%～2%,尽管大剂量化疗联合造血干细胞移植已应用于MM,但其仍难以治愈。近年来,细胞因子在多发性骨髓瘤的发生发展中的作用已广为重视,大量研究表明,胰岛素样生长因子-(IGF-)在骨髓瘤细胞的生长、存活、黏附、迁移以及相关的耐药过程中发挥重要作用。本文就IGF-在多发性骨髓瘤中作用及其相关机制作一综述。
Multiple myeloma (MM) is a B cell line malignant tumor characterized by a large number of malignant plasma cell proliferation in bone marrow with extensive osteolytic lesions. It occurs in the elderly and accounts for about 1% to 2% of the total human cancer incidence %, Although high-dose chemotherapy combined with hematopoietic stem cell transplantation has been applied to MM, it is still difficult to cure. In recent years, the role of cytokines in the occurrence and development of multiple myeloma has been given a lot of attention, a large number of studies have shown that insulin-like growth factor - (IGF-) in myeloma cells growth, survival, adhesion, migration and related resistance Drugs play an important role in the process. This article reviews the role of IGF-1 in multiple myeloma and its related mechanisms.