痛性周围神经病变是糖尿病的常见并发症,目前常用的减轻疼痛的措施包括简单镇痛剂、改善糖尿病控制、酰胺咪嗪以及三环抗抑郁药等,常因出现副作用而导致某些病人不得不停止治疗。 糖尿病神经痛的发病基础尚不明确,故很难采取针对性的特异治疗。在动物实验研究中,给予Capsaicin能使若干类型的致痛性应激所造成的感觉丧失;给人局部使用Capsaicin对于化学和热所致的疼痛有脱敏作用。本文作者试图观察Capsai-cin对糖尿病神经病变是否有镇痛效果。 Painful peripheral neuropathy is a common complication of diabetes. The commonly used measures to reduce pain include simple analgesics, improvement of diabetes control, amilizine and tricyclic antidepressants, which often result in side effects that may cause some patients to not Do not stop treatment. The basis of the pathogenesis of diabetic neuralgia is not clear, so it is difficult to take specific and specific treatment. In animal studies, administration of Capsaicin causes loss of sensation due to several types of painful stress; topical administration of Capsaicin gives desensitization to chemical and heat-induced pain. The authors attempted to observe whether Capsai-cin has an analgesic effect on diabetic neuropathy.