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目的探讨宫颈癌患者CD83和CD68的表达及其临床意义。方法用流式细胞术检测宫颈癌患者40例(A组)及宫颈良性病变患者30例(B组)的宫颈组织及外周血CD83和CD68的表达。结果 A组宫颈组织中CD83和CD68的表达分别为1.64±1.58和7.47±0.85,均明显低于B组的6.89±1.76和16.68±2.65(P<0.05);A组外周血中CD83和CD68的表达分别为1.36±1.24和6.68±1.35,均明显低于B组的5.74±1.39和15.46±2.14(P<0.05)。宫颈癌患者血中和宫颈组织中CD83和CD68的表达均无统计学差异,但均与肿瘤临床分期及淋巴结转移密切相关。结论宫颈癌患者宫颈组织及外周血中CD83和CD68的表达水平与肿瘤临床分期及预后密切相关;外周血CD83和CD68的表达水平可作为评估宫颈癌患者预后的检测指标。
Objective To investigate the expression of CD83 and CD68 in patients with cervical cancer and its clinical significance. Methods Flow cytometry was used to detect the expression of CD83 and CD68 in cervical tissue and peripheral blood in 40 patients with cervical cancer (group A) and 30 patients with benign cervical lesions (group B). Results The expression of CD83 and CD68 in group A were 1.64 ± 1.58 and 7.47 ± 0.85, respectively, which were significantly lower than those in group B (6.89 ± 1.76 and 16.68 ± 2.65, respectively) (P <0.05). In group A, the expression of CD83 and CD68 The expression levels were 1.36 ± 1.24 and 6.68 ± 1.35, respectively, which were significantly lower than those in group B (5.74 ± 1.39 and 15.46 ± 2.14, P <0.05). There was no significant difference in the expression of CD83 and CD68 in the blood and cervical tissue of cervical cancer patients, but both were closely related to the clinical stage and lymph node metastasis. Conclusion The expression levels of CD83 and CD68 in cervical tissue and peripheral blood of patients with cervical cancer are closely related to the clinical stage and prognosis of the patients. The expression levels of CD83 and CD68 in peripheral blood can be used as indexes to evaluate the prognosis of patients with cervical cancer.