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51例糖尿病肾病患者分为高血压组和正常血压组。4年来动态观察其血压、血糖、尿微白蛋白排泄率(AER)、肾功能。发现两组间血糖和糖化血红蛋白相差和变化不大。高血压组AER平均值和4年上升幅度均高于正常血压组(分别为P<0.001,P<0.005)。肾功能以1/cr·t~(-1)表示,两组首次肌酐值近似,4年中肾功损失程度按Mitch方法以斜率b表示,两组间差异显著(P<0.001)。提示高血压是糖尿病肾病进展中的危险因素。
51 patients with diabetic nephropathy were divided into hypertension group and normotensive group. 4 years dynamic observation of its blood pressure, blood glucose, urinary albumin excretion rate (AER), renal function. Found that blood glucose and glycosylated hemoglobin difference between the two groups and little changed. The mean and 4-year increase in AER in hypertension group were higher than those in normal blood pressure group (P <0.001, P <0.005, respectively). The renal function was expressed as 1 / cr · t ~ (-1). The first time creatinine values were similar in both groups. The degree of renal function loss in four years was expressed as slope b by Mitch method. There was significant difference between the two groups (P <0.001). Hypertension is a risk factor in the progression of diabetic nephropathy.