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由于抗肿瘤药物存在着多种毒性,因而临床应用受到限制。这些毒性包括胃肠上皮细胞损害和骨髓的破坏。因此,新的抗肿瘤药物应考虑到已知的或潜在的毒性和作用机制来设计.亚硝基脲是具活性的抗肿瘤药物,将DNA 烷基化为其机制。此类药中,还有几种可使细胞蛋白质氨甲酰基化的.由于氨甲酰基化与抗肿瘤效果无关,因而,人们认为临床上产生的副作用是由此而产生的.另一方面,迄今已有报道表明,有几种抗肿瘤药
Due to the variety of antitumor drugs, clinical application is limited. These toxicities include damage to the gastrointestinal epithelium and destruction of the bone marrow. Therefore, new antineoplastic agents should be designed with the known or potential toxicity and mechanism of action.Nitrosourea is an active antineoplastic agent that alkylates DNA into its mechanism. Of these, there are several other drugs that can be used to carbamylate cellular proteins, and because of the lack of carbamylation and antitumor effects, it is thought that the clinically-produced side effects are caused by the other, So far it has been reported that there are several anti-tumor drugs