目的开发一条适合产业化的3-氯-4-(3-氟苄氧基)苯胺的合成工艺路线。方法以间氟氯苄和2-氯-4-硝基苯酚为原料,依次经碳酸钾存在下的缩合反应、铁粉/氯化铵还原得到3-氯-4-(3-氟苄氧基)苯胺。结果总收率为82%。所得产物经TLC、熔点和核磁共振氢谱表征,具有高纯度。结论本方法原料价廉易得,操作简便,环境污染更小,预期适合工业化生产。 Objective To develop a synthetic route suitable for industrialization of 3-chloro-4- (3-fluorobenzyloxy) aniline. Methods 3-Chloro-4- (3-fluorobenzyloxy) -2-chloro-4-nitrophenol was prepared by the reaction of m- )aniline. The total yield was 82%. The resulting product was characterized by TLC, melting point and proton nuclear magnetic resonance spectroscopy, with high purity. Conclusion The method of raw materials cheap and easy, easy to operate, less environmental pollution, is expected to be suitable for industrial production.