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目的调查慢性乙型肝炎病毒感染者中2型糖尿病的流行情况,探讨慢性乙型肝炎感染患者2型糖尿病发病相关的危险因素。方法调查疾病预防控制中心门诊就诊的333例慢性HBV感染者临床资料、血生化、HBV血清学及病毒学指标,进行单因素和多因素回归分析。结果慢性乙型肝炎并发2型糖尿病在城市患者中的流行率明显高于农村和城镇。单因素分析显示,慢性乙型肝炎患者合并糖尿病的危险因素包括城市、糖尿病家族史、合并脂肪肝史、病毒定量、AKP、TG、CH,TBIL为保护因素。多因素分析显示:城市居民、TG异常、合并脂肪肝史、病毒定量是慢性乙型肝炎并发糖尿病的独立危险因素。结论对慢性乙型肝炎患者,尤其是城市居民,应注意监测TG、病毒定量,预防脂肪肝,以减少发生2型糖尿病的可能性。
Objective To investigate the prevalence of type 2 diabetes in patients with chronic hepatitis B virus infection and explore the risk factors associated with type 2 diabetes in patients with chronic hepatitis B infection. Methods The clinical data, blood biochemistry, HBV serology and virological indexes of 333 patients with chronic HBV infection from outpatient service of CDC were investigated. Univariate and multivariate regression analysis were performed. Results The prevalence of type 2 diabetes in patients with chronic hepatitis B was significantly higher in urban patients than in rural and urban areas. Univariate analysis showed that risk factors of diabetes mellitus in patients with chronic hepatitis B include urban, family history of diabetes, history of fatty liver, viral quantitative, AKP, TG, CH and TBIL as protective factors. Multivariate analysis showed that urban residents, abnormal TG, history of fatty liver, and viral quantification were independent risk factors of chronic hepatitis B complicated by diabetes. Conclusion Chronic hepatitis B patients, especially urban residents, should pay attention to monitoring TG, viral quantitative, prevention of fatty liver, in order to reduce the possibility of occurrence of type 2 diabetes.