论文部分内容阅读
目的 探讨生长抑素类似物善宁对肝部分切除术后种植性肝癌的作用及其相关机制。 方法 以Wistar大鼠种植性肝癌模型为研究对象 ,将 6 4只雄性Wistar大鼠随机分为 4组 ,每组 16只。A组行单纯右肝叶肿瘤种植 ,B、C、D组均行左肝叶切除加右肝叶肿瘤种植。C、D组分别为术后12h、72h开始首次善宁治疗组 (5 0ug/kg,腹腔内注射 ,每日 2次 )。A、B组为对照组 (生理盐水 ,方法与剂量同上 )。 结果 术后 1周 ,A组肿瘤体积明显小于B、C、D组 (P <0 0 1)。C、D组的肿瘤体积明显小于B组 (P <0 0 1) ,而肿瘤细胞的凋亡率则明显高于B组 (P <0 0 1)。C组与D组的肿瘤体积和细胞凋亡率之间亦存在显著差异 (P <0 0 1)。 结论 善宁可以抑制术后肝肿瘤的生长。
Objective To investigate the effect of somatostatin analogue shanning on implanted liver cancer after partial hepatectomy and its related mechanism. Methods Sixty Wistar rats were randomly divided into four groups with 16 rats in each group. In group A, a single right hepatic lobe tumor was implanted. In group B, C, and D, left hepatectomy and right hepatic lobe tumor were implanted. In group C and D, the first group of good-Ning treatment (50 μg/kg, intraperitoneal injection, twice daily) began at 12h and 72h after operation. A, B group as a control group (physiological saline, method and dose as above). Results One week after operation, the tumor volume in group A was significantly smaller than that in group B, C, and D (P < 0 01). The tumor volume in the C and D groups was significantly smaller than that in the B group (P < 0.01), while the apoptosis rate of the tumor cells was significantly higher than that in the B group (P <0 01). There was also a significant difference between tumor volume and apoptosis rate between group C and group D (P < 0 01). Conclusion Shanning can inhibit the growth of liver tumor after operation.