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目的探讨基质金属蛋白酶-14(MMP-14)和CD147的表达与胃肠间质瘤(GISTs)临床病理特征的关系。方法采用免疫组化SP法检测69例GISTs组织中MMP-14和CD147的表达,分析MMP-14和CD147与各病理参数的关系。结果 GISTs组织中MMP-14和CD147的阳性率分别为94.2%和97.1%,MMP-14阳性表达程度与GISTs的危险度、CD147表达及肿瘤的大小呈正相关(P<0.05);CD147阳性表达程度与肿瘤的大小呈正相关(P<0.05)。结论 MMP-14阳性表达与GISTs危险度关系密切,可作为GISTs危险度的潜在评价指标。
Objective To investigate the relationship between the expression of matrix metalloproteinase-14 (MMP-14) and CD147 and clinicopathological features of gastrointestinal stromal tumors (GISTs). Methods The expressions of MMP-14 and CD147 in 69 cases of GISTs were detected by immunohistochemical SP method. The relationship between MMP-14 and CD147 and the pathological parameters was analyzed. Results The positive rates of MMP-14 and CD147 in GISTs tissues were 94.2% and 97.1%, respectively. The positive expression of MMP-14 was positively correlated with the risk of GISTs, the expression of CD147 and the size of tumor (P <0.05) And tumor size was positively correlated (P <0.05). Conclusion The positive expression of MMP-14 is closely related to the risk of GISTs, which can be used as a potential evaluation index for the risk of GISTs.