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目的:探讨熊去氧胆酸对脂肪肝的临床疗效。方法:将我院感染性疾病科住院治疗的60例患者,给予熊去氧胆酸治疗,观察比较患者治疗前后甘油三酯(TG)、谷丙转氨酶(ALT)、胆固醇(TC)、谷草转氨酶(AST)和腹部B超的变化。结果:经过一个疗程的治疗后,所有患者均未出现较为明显的不良反应。其中有37例患者显效(61.67%),22例患者为有效(36.67%),无效患者1例(1.67%)。治疗后患者的谷丙转氨酶、谷草转氨酶、胆固醇、甘油三酯各项指标,与治疗前相比,差异显著,有统计学意义,p<0.05。结论:采用熊去氧胆酸治疗非酒精性脂肪肝,疗效显著,不良反应少,值得临床应用。
Objective: To investigate the clinical effect of ursodeoxycholic acid on fatty liver. Methods: Sixty patients hospitalized with Infectious Diseases in our hospital were treated with ursodeoxycholic acid. The levels of triglyceride (TG), alanine aminotransferase (ALT), cholesterol (TC), aspartate aminotransferase (AST) and abdominal ultrasonography. Results: After a course of treatment, all patients did not appear more obvious adverse reactions. Among them, 37 cases were markedly effective (61.67%), 22 cases were effective (36.67%) and 1 case was ineffective (1.67%). After treatment, alanine aminotransferase, aspartate aminotransferase, cholesterol, triglyceride various indicators, compared with before treatment, the difference was statistically significant, p <0.05. Conclusion: Ursodeoxycholic acid treatment of non-alcoholic fatty liver, significant effect, less adverse reactions, it is worth clinical application.