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【目的】分析位于十二指肠的胃肠道间质瘤(GIST)的临床诊断、治疗效果及其影响因素。【方法】对中山大学肿瘤防治中心1990年1月至2009年10月治疗的19例十二指肠GIST临床资料复核并加以随访回顾分析。所有参数均采用SPSS16.0统计软件处理,分析完全切除14例和不完全切除5例的生存率和有关影响因素。【结果】十二指肠GIST多见于十二指肠降部和水平部,最常见症状为消化道出血。全组1～、2～和5～年生存率分别为94.4%、77.3%和61.8%,完全切除术后1～、2～和5～年生存率分别为100%、80.0%和80.0%,不全切除术后为80%、0%和0%,完全切除术组患者生存率明显优于不完全切除术组(P<0.05)。完全切除组中局部切除和扩大切除之间无显著差异(P>0.05)。【结论】十二指肠GIST仍以外科治疗为主,其手术方式的选择更多取决于肿瘤的部位和大小,伊马替尼可改善患者预后。
【Objective】 To analyze the clinical diagnosis, treatment effect and influencing factors of gastrointestinal stromal tumors (GIST) located in the duodenum. 【Methods】 The clinical data of 19 cases of duodenal GIST from January 1990 to October 2009 in Sun Yat-sen University Cancer Center were reviewed and analyzed retrospectively. All parameters were used SPSS16.0 statistical software to analyze the complete resection of 14 cases and incomplete resection of the survival rate of 5 cases and related factors. 【Results】 Duodenal GIST was found in the descending part and the horizontal part of the duodenum. The most common symptom was gastrointestinal bleeding. The overall survival rates at 1, 2 and 5 years were 94.4%, 77.3% and 61.8% respectively. The survival rates at 1, 2 and 5 years after complete resection were 100%, 80.0% and 80.0%, respectively. The total survival rate of patients undergoing complete resection was significantly better than that of patients undergoing incomplete resection (P <0.05) after 80%, 0% and 0% of incomplete resection. There was no significant difference between local resection and extended resection in the resection group (P> 0.05). 【Conclusion】 Surgical treatment of GIST in duodenum is still the main choice. The choice of surgical approach depends on the location and size of tumor. Imatinib can improve the prognosis of patients.