目的探讨亲属肾移植供者术后早期肾功能变化的影响因素。方法选取2010年1月至2014年5月行肾移植手术的55例亲属肾源供者为研究对象,术后进行为期30 d随访,分析性别、年龄等因素对供者GFR水平及其代偿率的影响。结果术后≤50岁供者GFR均值、代偿率均明显高于>50岁,差异均有统计学意义(均P<0.05);男性供者术前、术后GFR均值均明显低于女性,差异有统计学意义(P<0.05);术前GFR水平≤50 ml/(min·1.73 m2)组的GFR均值术前、术后均明显低于术前GFR水平>50 ml/(min·1.73 m2)组,代偿率均值为59.1%,明显高于术前GFR水平>50 ml/(min·1.73 m2)组的43.9%,差异有统计学意义(P<0.05)。结论肾移植亲属供者术后保留侧肾脏GFR明显提高,年龄、性别、术前GFR水平等均为影响肾移植术后亲属供者早期肾功能的影响因素。 Objective To investigate the influencing factors of early renal function changes in relatives of kidney transplant recipients. Methods From January 2010 to May 2014, 55 relatives of renal allograft recipients were enrolled in this study. Patients were followed up for 30 days. Factors such as sex and age were analyzed for GFR levels and their compensations Rate of impact. Results The mean GFR and compensatory rate of the donors ≤50 years old were significantly higher than those> 50 years old (all P <0.05). The mean GFR of male donors before and after operation were significantly lower than those of women , The difference was statistically significant (P <0.05). The preoperative and postoperative GFR mean GFR values ​​of preoperative GFR ≤50 ml / (min · 1.73 m2) group were significantly lower than preoperative GFR> 50 ml / min 1.73 m2) group, the mean of compensation rate was 59.1%, which was significantly higher than 43.9% of the preoperative GFR level> 50 ml / (min · 1.73 m2) group, the difference was statistically significant (P <0.05). CONCLUSION: The GFR of the retained kidney in renal transplant relatives after operation is significantly increased. Age, sex and preoperative GFR levels are the influencing factors of early renal function of relatives after renal transplantation.