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本文讨论了绝经后妇女因体内雌激素水平降低,导致血清脂蛋白水平随之发生一些不利于该类妇女心血管系统的变化。雌激素替代治疗后可使绝经后升高的总胆固醇和LDL-C水平降低4％～19％,Lp.(a)水平降低14％～50％,减轻或抑制LDL的氧化过程并减轻氧化的LDL对细胞的毒性作用,还能使降低的HDL—C水平升高9％～20％,脂质代谢的这些变化可使绝经后妇女冠心病的发病率和病死率降低。对雌激素给药的途径,单用或与孕激素联用以及其最小有效治疗荆量等文内亦做了介绍。(吴姝葳摘)
This article discusses the postmenopausal women due to lower estrogen levels, resulting in the level of serum lipoprotein followed by some of these women’s cardiovascular system is not conducive to changes. Estrogen replacement therapy can reduce elevated levels of total cholesterol and LDL-C by 4% -19% and Lp. (A) by 14% -50%, reduce or inhibit LDL oxidation and reduce oxidative The toxic effects of LDL on cells also lead to a 9% to 20% reduction in HDL-C levels. These changes in lipid metabolism may reduce the incidence of coronary heart disease and mortality in postmenopausal women. The route of administration of estrogen, alone or in combination with progestin, and its minimal effective treatment are also described. (Wu Shu 葳 pick)