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珍珠是从珍珠贝科 Ptriidal 合浦珠母贝中取出的药用部分,用途甚广,因产量低,价格贵,近来用其珍珠层及水解产物作为药用珍珠的代用品,在临床上取得一定成果,可是用珍珠母贝之分泌生殖腺提取物作药用,国内外研究报导较少,以往多将珠母贝软体部分当海产品吃掉。为发掘海洋生物的药用资源,我们自1976年以来,对合浦珠母贝分泌生殖腺(包括外套膜粘液、精、卵)以提取原生物激素的方法,试制成珍珠Ⅱ号注射液,用于临床治疗肝炎、哮喘、更年期、青春期内分泌紊乱而致子宫功能性出血等病人,其中对子宫功能性出血有较好的疗效。一、珍珠Ⅱ号注射液生产工艺:取新鲜珍珠的外套膜粘液及生殖巢内的卵子、精子混合物,置冰箱4℃冷藏4天,加10％HC1调pH2,冷藏4天,用10％NaOH 调 pH9,再冷藏半小时,过滤所得溶液加总量0.5％活性炭,80℃加热10分钟趁热过滤,调
Pearl is a medicinal part taken out from pearl Beco Ptriidal phleopsis maximus. It has a wide range of applications. Due to its low yield and high price, it recently used its nacre and hydrolysate as substitutes for medicinal pearls and achieved certain results in clinical practice. However, there is less research report at home and abroad for the secretion of gonad extracts from mother-of-pearls for medicinal purposes. In the past, most of the pearl-shelled soft-shelled bodies were eaten as seafood. In order to discover the medicinal resources of marine organisms, since 1976, we have tried to prepare Pearl II injections by secreting gonads (including mantle, sperm, and eggs) from the mother oyster shells of Hepu to extract the original biological hormones. In the clinical treatment of hepatitis, asthma, menopause, adolescent endocrine disorders caused by uterine bleeding and other patients, which have a good effect on uterine functional bleeding. First, Pearl II injection production process: take the fresh pearl mantle mucosa and egg, sperm mixture in the reproductive nest, refrigerator 4 °C refrigerated for 4 days, plus 10% HC1 adjusted pH2, refrigerated for 4 days, with 10% NaOH Adjust the pH value, and then refrigerate for half an hour. Filter the resulting solution to add 0.5% total amount of activated charcoal and heat at 80°C for 10 minutes while hot-filtering.