论文部分内容阅读
目的分析干扰素抗肝炎病毒后诱发甲状腺功能异常的临床特点。方法收集我院干扰素治疗后新发甲状腺功能异常的慢性乙型或丙型病毒性肝炎患者28例,根据首次异常的甲状腺功能判定为甲亢或甲减,分别予口服甲状腺相关药物(甲巯咪唑或左甲状腺素)治疗,或无需甲状腺相关药物治疗,根据病情决定是否继续使用干扰素,随访6个月,分析干预药物疗效及影响。结果无论甲亢或者甲减患者,在继续使用干扰素的同时,予甲巯咪唑或左甲状腺素治疗后6个月,其甲状腺功能明显好转,肝炎病毒载量降低,差异有统计学意义(P<0.05),而亚临床甲亢或者亚临床甲减患者,未予甲状腺相关药物治疗,其甲状腺功能无变化,差异无统计学意义(P>0.05)。结论当干扰素抗肝炎病毒后诱发甲状腺功能异常时,对甲亢或甲减的适当临床干预,可保证干扰素治疗的进行,严格控制抗甲亢药物剂量,可减少不良反应的发生。
Objective To analyze the clinical features of interferon against hepatitis virus induced thyroid dysfunction. Methods Twenty-eight patients with chronic hepatitis B or C who had new-onset thyroid dysfunction after interferon treatment in our hospital were enrolled. According to the first abnormal thyroid function, Hyperthyroidism or hypothyroidism was assessed. Thyroid-related drugs (methimazole Or levothyroxine) treatment, or without thyroid-related drug treatment, depending on the condition decide whether to continue using interferon, followed up for 6 months, analysis of the efficacy and impact of intervention drugs. Results No matter hyperthyroidism or hypothyroidism, while continuing to use interferon, thymectomy was significantly improved and hepatitis viral load was decreased at 6 months after thymectim or levothyroxine treatment, with significant difference (P < 0.05). However, there was no significant difference in thyroid function between subclinical hyperthyroidism and subclinical hypothyroidism without thyroid-related drug treatment (P> 0.05). Conclusion When interferon induces thyroid dysfunction after anti-hepatitis virus, proper clinical intervention on hyperthyroidism or hypothyroidism can ensure the treatment of interferon. Strict control of anti-hyperthyroidism dose can reduce the incidence of adverse reactions.