Objective: To observe the effect of Fufang Jisheng Liujin Gao (复文寄生流浸膏 Compound Mistletoe Fluidextract) on blood pressure in the spontaneous hypertensive rats (SHR) and the renal hypertensive dogs (RHD). Methods: The blood pressure-decreasing effects of single administration and 14-day consecutive administration of Compound Mistletoe Fluidextract (CMF) in SHR and RHD were investigated and compared with that of Niuhuang Jiangya Wan (牛黄降压丸 Bezoar Hypertension-relieving Pills). Results: Both single administration and 14-day consecutive administration of CMF had significant hypotensive effects in SHR and RHD. Conclusion: The hypotensive action of CMF is gradual, but lasts for a longer period, with a dose-effect relationship in a range of doses.