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目的建立糖智宁胶囊的定量分析方法。方法采用HPLC测定糖智宁胶囊中葛根素、盐酸小檗碱、人参皂苷Ro和竹节参皂苷Ⅳa的含量。Kromasil C18色谱柱(4.6 mm×250 mm,5μm);柱温30℃;流动相为乙腈-0.2%磷酸溶液(梯度洗脱);流速1 ml·min-1;检测波长203 nm。结果 HPLC中,葛根素、盐酸小檗碱、人参皂苷Ro和竹节参皂苷Ⅳa线性范围分别为0.87~15.66μg(r=0.999 6)、1.84~40.48μg(r=1.000 0)、0.19~4.114μg(r=0.999 9)、3.24~71.28μg(r=0.999 9),平均加样回收率分别为98.14%、98.18%、98.69%、97.02%,RSD分别为0.51%、2.16%、1.39%、1.50%。结论该方法简单、专属性强、重复性好、结果准确可靠,可用于糖智宁胶囊的质量评价。
Objective To establish a quantitative analysis method of Tangzhi capsule. Methods The contents of puerarin, berberine hydrochloride, ginsenoside Ro and ginsenoside Ⅳa in Tangzhining capsule were determined by HPLC. Kromasil C18 column (4.6 mm × 250 mm, 5 μm); the column temperature was 30 ℃; the mobile phase was acetonitrile-0.2% phosphoric acid solution (gradient elution); the flow rate was 1 ml · min-1; Results The linear ranges of puerarin, berberine hydrochloride, ginsenoside Ro and sizinoside Ⅳa were 0.87 ~ 15.66μg (r = 0.999 6), 1.84 ~ 40.48μg (r = 1.000 0), 0.19 ~ 4.114 The average recoveries were 98.14%, 98.18%, 98.69%, 97.02%, RSD 0.51%, 2.16%, 1.39%, respectively. 1.50%. Conclusion The method is simple, specific, reproducible, accurate and reliable, and can be used for the quality evaluation of Tangzhining capsules.