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硫酸亚铁、维生素B_(12)、叶酸是临床治疗缺铁性贫血及营养不良性贫血的常用药物,其作用机理已被大家所熟知。但三种药物的剂量问题,意见不一。本文就此作一简述。硫酸亚铁目前临床应用很广,其口服吸收部位主要是在十二指肠,以亚铁离子的形式吸收,吸收方式是通过肠粘膜上皮细胞主动转运和被动扩散两种方式进行。每日饮食中的铁是主动吸收,当大剂量口服时则是以被动扩散为主。亚铁离子进入血液立即氧化为三价铁,并与血浆中的β球蛋白(即转铁蛋白)结合,运载到机体贮存部位,以供机体利用。
Ferrous sulfate, vitamin B_ (12) and folic acid are commonly used drugs for the clinical treatment of iron deficiency anemia and malnutritional anemia. The mechanism of action has been well known. However, the dose of three drugs, different views. This article makes a brief introduction to this. The clinical application of ferrous sulfate is very wide, the oral absorption of the site is mainly in the duodenum to ferrous ions in the form of absorption, absorption through the intestinal mucosal epithelial cells actively transported and passive diffusion in two ways. The daily diet of iron is active absorption, when the large doses of oral is based on passive proliferation. Ferrous ions into the blood immediately oxidized to ferric iron, and beta-globulin in plasma (ie transferrin), carried to the body storage site for the body to use.