The optimal control design for singularly perturbed time-delay systems affected by external disturbances is considered. Based on the decomposition theory of singular perturbation, the system is decomposed into a fast subsystem without time-delay and a slow time-delay subsystem with disturbances. The optimal disturbances rejection control law of the slow subsystem is obtained by using the successive approximation approach (SAA) and feedforward compensation method. Further, the feedforward and feedback composite control (FFCC) law for the original problem is developed. The FFCC law consists of linear analytic terms and a time-delay compensation term which is the limit of the solution sequence of the adjoint vector equations. A disturbance observer is introduced to make the FFCC law physically realizable. Numerical examples show that the proposed algorithm is effective.