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正电子放射X线断层扫描(PET)为活体大脑生理过程提供了定量的三维图象。根据精神分裂症多巴胺活性增高假说,应用PET测量经过治疗的精神分裂症病人基底节多巴胺D_2受体密度是很有意义的。但使用选择性的D_2标记的研究得到不同的结果。Farc1e等(1987)发现在壳核或尾状核,D_2受体数量没有增加。Wong等人(1989)的研究发现精神分裂症病人的D_2受体是增加的,随后发现躁郁性精神病人D_2受体也类似增加,提出了D_2受体过量是精神疾病特征的可能性。
Positron emission tomography (PET) provides a quantitative three-dimensional image of living brain processes. Based on the hypothesis of increased dopamine activity in schizophrenia, it is of interest to measure the density of basal ganglia dopamine receptors in treated schizophrenic patients using PET. However, studies using selective D 2 labeling yielded different results. Farc1e et al. (1987) found no increase in the number of D2 receptors in the putamen or caudate nucleus. The study of Wong et al. (1989) found that D 2 receptors were increased in schizophrenic patients, followed by a similar increase in D 2 receptors in bipolar disorder, suggesting the possibility that D 2 receptor overdose is a characteristic of psychiatric disorders.