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硝苯吡啶(Nifedipine)又各硝苯啶,商品名心痛定,其应用临床时间虽短,但对冠心病中各类心绞痛的治疗效果较佳。近年来,通过研究发现,硝苯吡啶有扩张全身血管、解除平滑肌痉挛,阻止血小板凝集、增加心肌氧供、防止 Ca~(++)超负荷、抑制多种受钙调节腺体的兴奋-分泌偶联等作用,因而被广泛用于各个系统疾病的治疗,现将该药临床效用综述如下。一、高血压病高血压病是心痛定近年来治疗最广的一种疾病。其机理在于心痛定能够封闭细胞膜上钙通道,阻断细胞器内钙释放。此外,该药还能阻断血管内皮细胞膜上的α受体,激活钙泵,从(?)扩张全
Nifedipine and nifedipine, trade name nifedipine, its clinical application of time is short, but the treatment of angina pectoris in coronary heart disease better. In recent years, through the study found that nifedipine to expand systemic blood vessels, relieve smooth muscle spasm, prevent platelet aggregation, increase myocardial oxygen supply, prevent Ca ~ (++) overload, inhibit a variety of calcium-regulated gland excitability - secretion Coupling and other effects, which are widely used in the treatment of various systemic diseases, the clinical efficacy of the drug are summarized below. First, hypertension Hypertension is painkilk set in the most widely treated in recent years, a disease. The mechanism is that nifedipine can block the cell membrane calcium channel, blocking organelle calcium release. In addition, the drug can also block the vascular endothelial cell membrane alpha receptors, activation of calcium pump, from the expansion of (?)