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目的研究大承气汤HPLC图谱中各峰与其药理作用的相关性。方法设计大承气汤不同的配伍,采用HPLC进行检测,对其49个色谱峰与药效进行相关性分析,研究本方化学成分与药效相关性。结果 11个色谱峰与药理效应Y1(小鼠小肠碳末推进率)之间的相关性具有显著性(P<0.05)或非常显著性(P<0.01);3个色谱峰与药理效应Y3(家兔肠管收缩频率)之间的相关性具有显著性(P<0.05)。结论厚朴酚、芦荟大黄素、大黄酸、大黄素、大黄酚及部分未知化学成分应为大承气汤发挥药效作用的物质基础,说明这些化学成分作为质量控制和工艺优化指标的合理性和科学性。
Objective To study the correlation between peaks in HPLC of Dachengqi Decoction and its pharmacological effects. Methods Different compatibility of Dachengqi Decoction was designed and tested by HPLC. Correlation analysis was made between 49 chromatographic peaks and pharmacodynamics, and the correlation between chemical composition and pharmacodynamics was studied. Results There was a significant (P <0.05) or very significant difference (P <0.01) between the 11 peaks and pharmacological effects of Y1 (small intestinal carbon advancing rate) Rabbit intestinal contractions frequency) was significantly (P <0.05). Conclusions Magnolol, aloe-emodin, rhein, emodin, chrysophanol and some unknown chemical components should be the material basis of Dachengqi Decoction for its pharmacodynamic effects, indicating the rationality of these chemical components as an indicator of quality control and process optimization And scientific.